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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AURKA
All Species:
21.82
Human Site:
S266
Identified Species:
32
UniProt:
O14965
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14965
NP_003591.2
403
45809
S266
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
Chimpanzee
Pan troglodytes
XP_525364
403
45791
S266
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
Rhesus Macaque
Macaca mulatta
XP_001098364
471
52859
F338
P
E
N
L
L
L
G
F
R
G
E
V
K
I
A
Dog
Lupus familis
XP_853397
405
45606
S267
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
Cat
Felis silvestris
Mouse
Mus musculus
P97477
395
44754
S257
P
E
N
L
L
L
G
S
N
G
E
L
K
I
A
Rat
Rattus norvegicus
P59241
397
44856
S259
P
E
N
L
L
L
G
S
N
G
E
L
K
I
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521399
303
34973
I171
G
S
D
G
E
L
K
I
A
D
F
G
W
S
V
Chicken
Gallus gallus
XP_425725
409
46456
R269
H
S
K
S
V
I
H
R
D
I
K
P
E
N
L
Frog
Xenopus laevis
Q91819
408
46443
S273
P
E
N
L
L
L
G
S
N
G
E
L
K
I
A
Zebra Danio
Brachydanio rerio
Q6NW76
320
36928
G188
N
L
L
L
G
Y
R
G
E
L
K
I
A
D
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VKN7
329
38282
D196
T
D
D
L
K
L
A
D
F
G
W
S
A
H
T
Honey Bee
Apis mellifera
XP_395732
327
37711
L195
R
D
I
K
P
E
N
L
L
L
G
I
K
G
E
Nematode Worm
Caenorhab. elegans
O01427
305
34731
G173
E
L
K
I
G
D
F
G
W
S
V
H
A
P
S
Sea Urchin
Strong. purpuratus
XP_001181990
278
32048
K146
L
G
L
L
G
D
L
K
I
A
D
F
G
W
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q683C9
282
32738
I150
I
K
P
E
N
L
L
I
G
A
Q
G
E
L
K
Baker's Yeast
Sacchar. cerevisiae
P38991
367
42927
I235
I
K
P
E
N
I
L
I
G
F
N
N
V
I
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
100
47.7
89.8
N.A.
82.6
83.6
N.A.
65.5
73.1
65.9
53.3
N.A.
38.4
53
46.6
50.6
Protein Similarity:
100
100
62.2
93
N.A.
86.8
87.3
N.A.
70.2
82.8
77.2
65.7
N.A.
57.8
67
56.3
60
P-Site Identity:
100
100
80
100
N.A.
93.3
93.3
N.A.
13.3
0
93.3
6.6
N.A.
20
6.6
0
6.6
P-Site Similarity:
100
100
86.6
100
N.A.
93.3
93.3
N.A.
20
26.6
93.3
20
N.A.
33.3
20
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
46.4
38.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55.3
57.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
7
0
25
13
0
0
19
0
44
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
13
13
0
0
13
0
7
7
7
7
0
0
7
0
% D
% Glu:
7
44
0
13
7
7
0
0
7
0
44
0
13
0
7
% E
% Phe:
0
0
0
0
0
0
7
7
7
7
7
7
0
0
7
% F
% Gly:
7
7
0
7
19
0
44
13
13
50
7
13
7
7
0
% G
% His:
7
0
0
0
0
0
7
0
0
0
0
7
0
7
0
% H
% Ile:
13
0
7
7
0
13
0
19
7
7
0
13
0
50
0
% I
% Lys:
0
13
13
7
7
0
7
7
0
0
13
0
50
0
13
% K
% Leu:
7
13
13
63
44
63
19
7
7
13
0
38
0
7
7
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
0
44
0
13
0
7
0
19
0
7
7
0
7
0
% N
% Pro:
44
0
13
0
7
0
0
0
0
0
0
7
0
7
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% Q
% Arg:
7
0
0
0
0
0
7
7
7
0
0
0
0
0
0
% R
% Ser:
0
13
0
7
0
0
0
38
0
7
0
7
0
7
13
% S
% Thr:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% T
% Val:
0
0
0
0
7
0
0
0
0
0
7
7
7
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
7
0
7
0
7
7
0
% W
% Tyr:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _